246 Assessment of the Quality of Methodological Rigour and Reporting of Clinical Practice Guidelines for the Management of Allergic Rhinitis—Qugar Study

nasal obstruction) were recorded before challenge and every 15 minutes after challenge initiation. For the evaluation of nasal obstruction, we used visual analog scales (VASs); subjects marked a site on a 10-cm line corresponding to the symptom severity on which absence of symptoms was designated as 0 and worst imaginable symptom as 10. PIFR was measured using an In-check flow meter and nasal resistance was measured using Rhino. The cross-sectional area in the nasal cavity was also measured using AR before and after challenge as an indicator of nasal obstruction. Results: When the volunteers with cedar pollinosis were exposed to cedar pollen in ACC, pollinosis symptoms were induced significantly. Changes in the 3 symptoms (sneezing frequency, nose-blowing frequency, nasal obstruction) were investigated before and after challenges on 2 consecutive days. No significant symptoms were induced on the first day of challenge in the non-pollen season. However, each of the 3 symptoms became more severe with second day of challenge, and a significant increase was seen in cumulative values by the second day. In terms of the allergen challenge test, we found a significant correlation between nasal obstruction symptom (VAS) and PIFR, but not AR and Rhino. Conclusions: PIFR after allergen challenge is more sensitive than AR or Rhino in detecting nasal obstruction using the allergen challenge chamber. Background: The edematous irritation of the corium of the pituitary mucosa wakes it suffers a degeneration that causes what is known as nasal polyposis, hypertrophy of the nasal mucosa as a result of a chronic inflamatory process. It is said that its formation is due to infectious processes, vascular changes as local disorders of the immunity of the nasal mucosa. However many concide in including the allergic factors as the cause of the nasal polypos and they give a special interest to the constitutional factor inside the genesis of them. The investigation had as objectives to know the relationship that there is between the nasal polyposis and the allergic diseases, as well as to study some parameters of the humoral and celular immunity in our patients. Methods: 15 patients diagnosed wiht nasal polyposis were taken from the otorhinolaryngologists and they were sent to the allergic department to be evaluated. Patient's charts of all of thems were made and they were indicated some studies such as eosinophil global count, nasal exudate,sample radio-graphic study of paranasal sinus, serology, hemogram, glycemia and minimal clotting test, study …